Defensin (LL-37)

Dhs. 505.00 AED

In stock

LL-37 is an innate immune peptide and the only cathelicidin found in humans. It is derived from the precursor protein hCAP18 and triggers a cascade of antimicrobial defense responses. PurePeptides offers LL-37 at over 98% purity for research purposes.

LL-37 is a 37-amino-acid antimicrobial peptide produced by the proteolytic cleavage of the human cathelicidin precursor protein hCAP18. Cathelicidin refers to a family of antimicrobial peptides, while hCAP18 is the precursor from which mature LL-37 is released. These terms are related but are not interchangeable.

In laboratory models, LL-37 is studied for its potential roles in:

Disrupting the integrity of bacterial, fungal, and viral membranes.
Activating neutrophils, macrophages, and T cells, and enhancing interferon-gamma production.
Modulating Toll-like receptors (TLRs) and reducing the expression of pro-inflammatory cytokines in chronic inflammation models.
Promoting angiogenesis and tissue regeneration, particularly in the skin and mucous membranes.

These findings are based on laboratory models and should not be interpreted as evidence of clinical efficacy in humans.

Available in a syringe pen format. After opening, store at a temperature of no more than +5°C and protect from light.

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